The Dalton Lab
Our lab studies the genes essential for life (i.e. we need them to survive).
These genes:
Underlie many rare diseases, such as Congenital Disorders of Glycosylation (CDGs) and aminoacyl-tRNA synthetase (ARS) deficiencies.
Represent rich, untapped biology due to interconnected pathways and challenges in modeling null mutations.
Are well-conserved and thereby great to study with model organisms - like fruit flies!
Some of the things our lab does:
Drug screens for therapeutics and biology
Making and phenotyping new models in flies and cells
Testing human cell lines to determine the impact of pathways and treatments
Unexplored-but-exciting ideas like aging and retrocopy analysis of essential genes
Please see research for more information!
News
Mar 2025Welcome Mandi Wild, our first graduate student! Mandi will be studying glycosylation disorders and their relation to degradation pathways (ERAD) and more.
Mar 2025Hans presented at the 2025 Drosophila Meeting in San Diego.
Jan 2025Our first “Super Lab Meeting” with Drs. Emily Beck, Allie Graham, and Coral Zhou! Thanks to all rotation students, and great presentations Aidan O’Hara and Zach Opoka!
Nov 2024Hans presented at the 2024 ASHG annual meeting in Denver.
Oct 2024We published our DPAGT1 drug screen work in PLOS Genetics, finishing a postdoctoral project from the Chow Lab.
Aug 2024The Dalton Lab officially opened on August 19th, 2024.
May 2024Hans presented at the KU Center for Genomics Symposium.
Mar 2024Hans spoke at The Allied Genetics Conference and presented a poster at the 2024 Sanford Burnham Prebys Rare Disease Day Symposium.
Jan 2024This website is created — our lab is officially starting!