Publications
Group highlights
At the end of this page, you can find the full list of publications.
Using a drug repurposing screen, we find multiple therapeutics capable of improving a model of DPAGT1-CDG. Specifically, we identify dopamine signaling as a new potential therapeutic and new interacting pathway.
Hans M. Dalton, Naomi J. Young, Alexys R. Berman, Heather D. Evans, Sydney J. Peterson, Kaylee A. Patterson, Clement Y. Chow
Using inhibitory drugs, we perform two cell-based screens with CRISPR technology to determine which genes are important under DPAGT1 inhibition. We then used a living fly, that models DPAGT1-CDG in the eye, in order to determine which of the top screened genes can improve its impaired eye development. Surprisingly, we found that inhibiting other CDG-causing genes, such as our top hit Dpm1, could improve our DPAGT1-CDG cell and fly models.
Hans M. Dalton(1), Raghuvir Viswanatha(1), Roderick Brathwaite Jr., Jae Sophia Zuno, Alexys R. Berman, Rebekah Rushforth, Stephanie E. Mohr, Norbert Perrimon, Clement Y. Chow (1 = contributed equally)
Full List of publications
A drug repurposing screen reveals dopamine signaling as a critical pathway underlying potential therapeutics for the rare disease DPAGT1-CDG
Hans M. Dalton, Naomi J. Young, Alexys R. Berman, Heather D. Evans, Sydney J. Peterson, Kaylee A. Patterson, Clement Y. Chow
PLOS Genetics (2024)
A genome-wide CRISPR screen identifies DPM1 as a modifier of DPAGT1 deficiency and ER stress
Hans M. Dalton(1), Raghuvir Viswanatha(1), Roderick Brathwaite Jr., Jae Sophia Zuno, Alexys R. Berman, Rebekah Rushforth, Stephanie E. Mohr, Norbert Perrimon, Clement Y. Chow (1 = contributed equally)
PLOS Genetics (2022)
Decoupling of Apoptosis from Activation of the ER Stress Response by the Drosophila Metallopeptidase superdeath
Rebecca A. S. Palu, Hans M. Dalton, Clement Y. Chow
Genetics (2020)
Air Pollution Alters Caenorhabditis elegans Development and Lifespan: Responses to Traffic-Related Nanoparticulate Matter
Amin Haghani(1), Hans M. Dalton(1), Nikoo Safi, Farimah Shirmohammadi, Constantinos Sioutas, Todd E. Morgan, Caleb E. Finch, Sean P. Curran (1 = contributed equally)
The Journals of Gerontology Series A (2019)
Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infection
James D. Nhan, Christian D. Turner, Sarah M. Anderson, Chia-An Yen, Hans M. Dalton, Hilary K. Cheesman, Dana L. Ruter, Nandhitha Uma Naresh, Cole M. Haynes, Alexander A. Soukas, Read Pukkila-Worley, Sean P. Curran
Proceedings of the National Academy of Sciences (2019)
Hypodermal responses to protein synthesis inhibition induce systemic developmental arrest and AMPK-dependent survival in Caenorhabditis elegans
Hans M. Dalton, Sean P. Curran
PLOS Genetics (2018)
Omega-3 and -6 fatty acids allocate somatic and germline lipids to ensure fitness during nutrient and oxidative stress in Caenorhabditis elegans
Dana A. Lynn, Hans M. Dalton, Jessica N. Sowa, Meng C. Wang, Alexander A. Soukas, Sean P. Curran
Proceedings of the National Academy of Sciences (2015)
Gain-of-function mutation in Gnao1: A murine model of epileptiform encephalopathy (EIEE17)?
Jason M. Kehrl, Kinshuk Sahaya, Hans M. Dalton, Raelene A. Charbeneau, Kevin T. Kohut, Kristen Gilbert, Madeline C. Pelz, Jack Parent, Richard R. Neubig
Mammalian Genome (2014)